Alzheimer’s Disease and CBD
Alzheimer’s Disease is one of the biggest social and medical challenges of our time. Alzheimer’s Disease (AD) is currently ranked as the sixth leading cause of death in the United States. Recent estimates indicate that the disorder may actually rank third – just behind heart disease and cancer, as a cause of death in the elderly [Alzheimer Fact Sheet]. And if you are planning to live into your 80s and beyond, you may have a 1 in 2 chance of getting Alzheimer’s in you lifetime.
More than 40 million suffer worldwide from Alzheimer’s Disease. Yet little progress has been made to fight the disease since its discovery over 100 years ago…
Alzheimer’s Is Not Normal Aging – And Can Be Cured | 8 min
AD is the predominant cause of dementia, with early symptoms being short-term memory loss, progressive loss of speech, mood swings, disorientation, loss of motivation and the inability to manage one’s self care. AD is characterized by an accumulation of amyloid-B plaques and hyperphosphorylated tau protein tangles (NFTs) [Watt G and Karl T Front Pharmacol]. CBD and THCV have a demonstrated ability to reduce these so-called NFTs [Esposito G Journal Molecular Medicine]5 and to regulate microglial cell migration in a manner that might actually reduce neuronal death associated with AD [Walter L Journal Neuroscience].
Published in the May 2014 edition of the Journal of Alzheimer’s Disease [Cheng D, Spiro AS 2014 May], Cheng, Spiro and associates obtained mice that were genetically modified (a transgenic model of AD) to simulate AD – and administered daily doses of CBD from 2.5 months of age till they were 8 months old. The mice were assessed daily with maze tests, fear conditioning paradigms, social preference tests and more. The scientists discovered that the AD mice that were provided daily doses of CBD, did not develop “social recognition deficits.” In addition, the scientists observed that the CBD treated mice possessed overall improved cognition when compared to the mice that didn’t receive any CBD.
How much CBD did these mice received each day? – Approximately the adult equivalent of 1.5 grams of CBD daily.
Although the cause of AD is currently unknown, the majority of risk is attributed to genetic factors, with additional risk factors including hypertension, head trauma and chronic depression [Watt G and Karl T Front Pharmacol].